Calcium Signals Lab (CSL)

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Professor David Yue passed away unexpectedly from a cardiac arrest on Dec 23, 2014.
In Memoriam
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Some treasured analogies that Dr. Yue used in his lectures

Recent Articles

Apocalmodulin itself promotes ion channel opening and Ca2+ regulation 

Multiscale optical Ca2+ imaging of tonal organization in mouse auditory cortex 

Conservation of Ca2+/calmodulin regulation across Na and Ca2+ channels 

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca2+ currents ... 

Calmodulin regulation (calmodulation) of voltage-gated calcium channels (review in J Gen Physiol) 

Allostery in Ca2+ channel modulation by calcium-binding proteins 

Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels. 

Continuously tunable Ca2+ regulation of RNA-edited CaV1.3 channels. 

Nanodomain Ca2+ of Ca2+ channels detected by a tethered genetically encoded Ca2+ sensor 

Enzyme-inhibitor-like tuning of Ca2+ channel connectivity with calmodulin.
(Faculty of 1000 evaluation.)
(Science Signaling Commentary)

Mechanism of Local and Global Ca2+ Sensing by Calmodulin in Complex with a Ca2+ Channel

A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels

The two faces of calmodulin


CSL publishes novel brain imaging technique in the journal Neuron.

Manu Ben Johny, wins the Nupur Dinesh Thekdi Award.

David Yue wins the 2011 Kenneth S. Cole Award.

CSL Student, Ivy Dick, wins the Siebel Scholars Award.
(Article) (Profile)

CSL students win Young Investigator Awards

David Yue wins hopkins wide teaching award

Sample PhD Projects

Perspectives on the scientific career for the aspiring researcher

David T. Yue, M.D., Ph.D.
Biomedical Engineering, Neuroscience, and Center for Cell Dynamics
Ross Bldg., Rm. 713/715
Email: [email protected]
Office: (410) 955-0078
Lab: (410) 955-0079
Fax: (410) 614-8269
Johns Hopkins University
Biomedical Engineering Department
720 Rutland Avenue,
713 Ross Building
Baltimore, MD21205

Lab administrator:Deon Grant
(410) 614-8624