Selected Publications

  1. Ben Johny, M., Yang, P.S., Hazzazi, H., and Yue, D.T. (2013). Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels.  Nature Communications (in press).
  2. Tay, L. H., Dick, I. E., Yang, W., Griesbeck, O. and Yue, D.T. (2012).  Nanodomain Ca2+ of Ca2+ channels detected by a tethered genetically encoded Ca2+ sensor.  Nature Communications | 3:778 | DOI:10.1038/ncomms1777.
  3. Huang, H., Tan, B. Z., Shen, Y., Tao, J., Jiang, F., Sung, Y. Y., Ng, C. K., Raidar, M., Kohr, G., Higuchi, M., Fatemi-Shariatpanahr, H., Harden, B., Yue, D.T. and Soong, T.W. (2012).  RNA editing of the IQ domain of CaV1.3 channels modulates their Ca2+-dependent inactivation.  Neuron 73:304-316.
  4. Sun, T., Wu, X.S., Xu, J., McNeil, B.D., Pang, Z.P., Yang, W., Bai, L., Qadri, S., Molkentin, J.D., Yue, D.T. and Wu, L.G. (2010).  The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses.  J. Neurosci. 30:11838-11847.PMID: 20810903.
  5. Tadross, M.R., and Yue, D.T. (2010).  Systematic mapping of the state-dependence of voltage and Ca2+-dependent inactivation using simple open-channel measurements.   J. Gen. Physiol. 135:217-227.
  6. Tadross, M.R., Johny, M.B., and Yue, D.T. (2010).  Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of CaV1.3 channels.   J. Gen. Physiol. 135:197-215. (Commentary by J Cui (2010) DOI: 10.1085/jgp.201010421).
  7. Liu, X., Yang, P.S., Yang, W., and Yue, D.T. (2010).  Enzyme-inhibitor-like tuning of Ca2+ channel connectivity with calmodulin.   Nature 463:968-972. (Editor's choice, Sci Signal 3:ec62;Faculty 1000 commentary)
  8. Tadross, M.R., Park, S.A., Veeramani, B., and Yue, D.T. (2009).  Robust approaches to quantitative ratiometric FRET imaging of CFP/YFP fluorophores under confocal microscopy.  J. Microscopy 233:192-204.
  9. Miriyala, J., Nguyen, T., Yue, D.T. , and Colecraft, H.M. (2008).  Role of CaVb subunits, and lack of functional reserve, in protein kinase A modulation of cardiac CaV1.2 channels.  Circ Res 102:e54-64
  10. Tadross, M.R., Dick, I.E., and Yue, D.T. (2008).  Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel.  Cell133:1228-1340. 
  11. Mori, M.X., Vander Kooi, C.W., Leahy, D.J., and Yue, D.T. (2008).  Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin: High-resolution mechanistic implications for channel regulation by Ca2+.  Structure 16:607-620. 
  12. Dick, I.E., Tadross, M.R., Liang, H., Tay, L.H., Yang, W., and Yue, D.T. (2008).  A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels.  Nature 451:830-834.
  13. Samuels, B.A., Hsueh, Y.P., Shut, T., Liang H., Tseng, H.C., Hong, C.J., Su, S.C., Volker, J., Neve, R.L., Yue, D.T., and Tsai, L.H. (2007).  Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.  Neuron 56:823-837. 
  14. Tay, L.H., Griesbeck, O., and Yue, D.T.  (2007).  Live-cell transforms between Ca2+ transients and FRET responses for a Troponin-C based Ca2+ sensor.  Biophys. J.  93:4031-4040.
  15. Chaudhuri, D., Issa, J.B., and Yue, D.T.  (2007).  Elementary mechanisms producing facilitation of CaV2.1 (P/Q-type) channels.  J. Gen. Physiol.  129:385-401.  (see Commentary  by K. Dunlap in Journal of General Physiology 129:379-383; 2008 Cranefield award to Chaudhuri, D.)   
  16. Herzig, S., Khan, I.F., Grundemann, D., Matthes, J., Ludwig, A., Michels, G., Hoppe, U.C., Chaudhuri, D., Schwartz, A., Yue, D.T., and Hullin, R.  (2007).  Mechanism of CaV1.2 channel modulation by the amino terminus of cardiac b2-subunits.  FASEB J. 21:1527-1538.
  17. Shen, Y., Yu, D., Hiel, H., Liao, P., Yue, D.T., Fuchs, P.A., and Soong, T.W. (2006).  Alternative splicing of the CaV1.3 channel IQ domain, a molecular switch for Ca2+-dependent inactivation within auditory hair cells. J. Neurosci. 26:10690-10699
  18. Yang, P.S., Alseikhan, B.A., Hiel, H., Grant, L., Mori, M.X., Yang, W., Fuchs, P.A., and Yue, D.T. (2006).  Switching of Ca2+-dependent inactivation of CaV1.3 channels by calcium binding proteins of auditory hair cells.  J. Neurosci. 26:10677-10689. 
  19. Liao, P., Yong, T.F., Liang, M.C., Yue, D.T., Soong, T.W. (2005).  Splicing for alternative structures of CaV1.2 Ca2+ channels in cardiac and smooth muscles.  Cardiovasc Res. 68:197-203.
  20. Takahashi, S.X., Miriyala, J., Tay, L.H., Yue, D.T., and Colecraft, H.M. (2005).  A CaVß SH3/guanylate kinase domain interaction regulates multiple properties of voltage-gated Ca2+ Channels. J. Gen. Physiol. 126:365-377.
  21. Chaudhuri, C., Alseikhan, B.A., Chang, S.Y., Soong, T.W., and Yue, D.T.  (2005).  Developmental activation of calmodulin-dependent facilitation of cerebellar P-type Ca2+ current. J. Neurosci.  25:8282-8294.
  22. Agler, H.L., Evans, J., Tay, L.H., Anderson, M.J., Colecraft, H.M., and Yue, D.T. (2005).  G-protein gated inhibitory module of N-type Ca channels. Neuron 46:891-904.
  23. Tang, Z.Z., Liang, M.C., Lu, S., Yu, D., Yu, C.Y., Yue, D.T., and Soong, T.W. (2004).  Transcript scanning reveals novel and extensive splice variations in human l-type voltage-gated calcium channel, Cav1.2 alpha1 subunit.  J Biol Chem. 279:44335-44443.
  24. Chaudhuri, D., Chang, S.Y., DeMaria, C.D., Alvania, R.S., Soong, T.W., and Yue, D.T. (2004). Alternative splicing as a molecular switch for Ca2+/calmodulin-dependent facilitation of P/Q-type Ca2+ channels. J. Neurosci. 24:6334-6342.
  25. Mori, M.X., Erickson, M.G., and Yue, D.T. 2004. Functional stoichiometry and local enrichment of calmodulin interacting with Ca2+ channels. Science | Full Text 304 :432-5 (see Perspectives in Science 304 :394-5; and Highlights in Nature Reviews Neuroscience 5 :432 ).
  26. Liang, H., DeMaria, C.D., Erickson, M.G., Mori, M.X., Alseikhan, B.A., and Yue, D.T. 2003. Unified mechanisms of Ca2+ regulation across the Ca2+ channel family. Neuron 39 :951-960.
  27. Evans, J., and Yue, D.T. 2003. New turf for CFP/YFP FRET imaging of membrane signaling molecules. Neuron 38 :145-152.
  28. Erickson, M.G., Liang, H., Mori, M.X., and Yue, D.T. 2003. FRET two-hybrid mapping reveals function and location of L-type Ca2+ channel CaM preassociation. Neuron 39 :97-107.
  29. Erickson, M.G., Moon, D.L., and Yue, D.T. 2003. DsRed as a potential FRET partner with CFP and GFP. Biophys. J. 85 :599-611.
  30. Agler, H.L., Evans, J. Colecraft, H.M., and Yue, D.T. 2003. Custom distinctions in the interaction of G-protein b subunits with N-type (Ca V 2.2) versus P/Q-type (Ca V 2.1) calcium channels. J. Gen. Physiol. 121 :495-510.
  31. Alseikhan, B.A., DeMaria, C.D., Colecraft, H.M., and Yue, D.T.   2002.  Engineered calmodulins reveal unexpected eminence of Ca channel inactivation in controlling heart excitation.  Proc. Natl. Acad. Sci. U.S.A.   99 :17185-17190.
  32. Soong, T.W., DeMaria, C.D., Alvania, R.S., Zweifel, L.S., Liang, M.C., Mittman, S., Agnew, W.S., and Yue, D.T. 2002. Systematic identification of splice variants in human P/Q-type channel a 2.1 subunits: Implications for current density and Ca2+-dependent inactivation.  J. Neurosci.  22 :10142-10152.
  33. Deschenes, I., Neyroud, N., Di Silvestre, D., Marban, E., Yue, D.T. , and Tomaselli, G.F.  2002.  Isoform-specific modulation of voltage-gated Na+ channels by calmodulin. Circ. Res. 90 :E49-57.
  34. Colecraft, H.M., Alseikhan, B.A., Takahashi, S.X., Chaudhuri, D., Mittman, S., Yegnasubramanian, V., Alvania, R.S., Johns, D.C., Marban, E., and Yue, D.T.   2002.  Novel functional properties of Ca2+ channel beta subunits revealed by their expression in adult rat heart cells.  J. Physiol. 541 :435-52.
  35. Erickson, M.G., Alseikhan, B.A., Peterson, B.Z., and Yue, D.T.   2001.  Preassociation of calmodulin with voltage-gated Ca2+ channels revealed by FRET in single living cells.  Neuron 31 :973-985.  
  36. DeMaria, C.D., Soong, T.W., Alseikhan, B.A., Alvania, R.S., and Yue, D.T.   2001.  Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels.  Nature 411 :484-489.
  37. Colecraft, H.M., Brody, D.L., and Yue, D.T.   2001.  G-protein inhibition of N- and P/Q-type calcium channels: distinctive elementary mechanisms and their functional impact.  J. Neurosci. 21 :1137-1147.
  38. Brody, D.L., and Yue, D.T.   2000.  Release-independent short-term synaptic depression in cultured hippocampal neurons.  J. Neurosci. 20 :2480-2494.
  39. Colecraft, H.M., Patil, P.G., and Yue, D.T.  2000.  Differential occurrence of reluctant openings in G-protein-inhibited N- and P/Q-type calcium channels.  J. Gen. Physiol. 115 :175-192.
  40. Peterson, B.Z., Lee, J.S., Mulle, J.G., Wang, Y., de Leon, M., and Yue, D.T.   2000.  Critical determinants of Ca2+-dependent inactivation within an EF-hand motif of L-type Ca2+ channels.  Biophys. J. 78 :1906-1920.
  41. Brody, D.L., and Yue, D.T. 2000.  Relief of G-protein inhibition of calcium ­ channels and short-term synaptic facilitation in cultured hippocampal neurons.  J. Neurosci. 20 :889-898.
  42. Wei, S.K., Colecraft, H.M., DeMaria, C.D., Peterson, B.Z., Zhang, R., Kohout, T.A., Rogers, T.B., and Yue, D.T. 2000.  Calcium-channel modulation by recombinant auxiliary beta subunits expressed in young adult heart cells.  Circ. Res. 86 :175-184.
  43. Jones, L. P., C. D. DeMaria, and Yue, D. T. 1999. N-Type calcium channel inactivation probed by gating-current analysis. Biophys J. 76 : 2530-52. [PubMed Abstract]
  44. Peterson1 , B. Z., C. D. DeMaria1 , J. P. Adelman, and Yue, D.T . 1999. Calmodulin is the Ca2+ sensor for Ca2+-dependent inactivation of L-type calcium channels. Neuron. 22 : 549-58. 1co-first authors. [PubMed Abstract]
  45. Jones, L.P., Wei, S-.K., and Yue, D.T. 1998. Mechanism of axuiliary-subunit modulation of neuronal a 1E calcium channels. J. Gen. Physiol. 112 :125-143. [PubMed Abstract]
  46. Patil, P.G., Brody, D.L., and Yue, D.T. 1998. Preferential closed-state inactivation of neuronal calcium channels. Neuron 20 :1027-1038. [PubMed Abstract]
  47. Yue D.T. 1997. Quenching the spark in the heart. Science 1997 276:755-6.
  48. Cai, D.M., Mulle, J.G., and Yue, D.T. (1997). Inhibition of recombinant Ca2+ channels by benzothiazepines and phenylalkylamines: class-specific pharmacology and underlying molecular determinants. Molecular Pharmacol 51 :872-881. [PubMed Abstract]
  49. Brody, D.L., Patil, P.G., Mulle, J.G., Snutch, T.P., and Yue, D.T. (1997). Bursts of action potential waveforms relieve G-protein inhibition of recombinant P/Q-type Ca2+ channels. J. Physiol. (Lond.) 499 :637-644. [PubMed Abstract]
  50. Jones, L.P., Patil, P.G., Snutch, T.P., and Yue, D.T. 1997. G-protein modulation of N-type calcium channel gating current. J. Physiol. (Lond.) 498 :601-610. [PubMed Abstract]
  51. Patil, P.G., de Leon, M., Reed, R.R., Dubel, S., Snutch, T.P., and Yue, D.T. 1996. Elementary events underlying voltage-dependent G-protein inhibition of N-type calcium channels. Biophys. J. 71 :2509-2521. [PubMed Abstract]
  52. Bourinet, E., Zamponi, G.W., Stea, A., Soong, T.W., Lewis, B.A., Jones, L.P., Yue, D.T. , and Snutch, T.P. 1996. The a 1E calcium channel exhibits permeation properties similar to low voltage-activated calcium channels. J. Neurosci. 16 :4983-4993. [PubMed Abstract]
  53. de Leon, M., Wang, Y., Jones, L., Perez-Reyes, E., Wei, X., Soong, T.W., Snutch, T.P., and Yue, D.T. 1995. Essential Ca2+-binding motif for Ca2+-sensitive inactivation of L-type Ca2+ channels. Science 270 :1502-1506. [PubMed Abstract]
  54. Wiechen, K., Yue, D.T. , and Herzig, S.W. 1995. Two distinct functional effects of protein phosphatase inhibitors on guinea-pig cardiac L-type Ca channels. J. Physiol. (Lond.) , 484 :583-592. [PubMed Abstract]
  55. Dobrunz, L.E., Backx, P.H., and Yue, D.T. 1995. Steady-state [Ca2+]i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53 998. Biophys. J . 69 :189-201. [PubMed Abstract]
  56. Imredy, J.P., and Yue, D.T. 1994. Mechanism of Ca-sensitive inactivation of L-type Ca channels. Neuron 12 :1301-1318. [PubMed Abstract]
  57. Herzig, S., Patil, P., Neumann, J., Staschen, C-M., and Yue, D.T. 1993. Mechanisms of beta-adrenergic stimulation of cardiac Ca2+ channels revealed by discrete-time Markov analysis of slow gating. Biophys. J. 65 :1599-1612. [PubMed Abstract]
  58. Yue, D.T. 1993. Bridging the gap between anomalous Na channel molecules and aberrant physiology. Biophys. J. 65 :13-14.
  59. Gingrich, K.J., Beardsley, D.T., and Yue, D.T. 1993. Ultra-deep blockade of Na channels by a quaternary ammonium ion: Catalysis by a transition-intermediate state? J. Physiol. (Lond.) 471 :319-341. [PubMed Abstract]
  60. Imredy, J.P. and Yue, D.T. 1992. Submicroscopic Ca2+ diffusion mediates inhibitory coupling between individual Ca channels. Neuron 9 :197-207. [PubMed Abstract]
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David T. Yue - Publications and Abstracts