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Ca Signals in Biological Systems (580.427/580.633)
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| Hot New Data! | ||
Contracting 19-day-old cardiomyocytes differentiated from human induced pluripotent stem cells | ||
| Course Description: | ||
Calcium is a universal and versatile messenger that directly regulates diverse biological processes including muscle contraction, neurotransmission, and hormonal secretion. This course develops a quantitative treatment of mechanisms generating distinct calcium signals, and the transduction of such signals into biological responses. Examples will be drawn extensively from heart cells and neurons, as well as non-excitable cells. Topics covered include: experimental approaches to measuring intracellular calcium dynamics, physical basis and mathematical modeling of calcium dynamics and homeostasis, and mechanisms of decoding calcium signals. Clinical implications of calcium dysregulation will also be discussed. |
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| Meeting Times: Syllabus (PDF) | ||
Lectures: W,F 3:30-5:00p, Ross 529 |
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| Contacts: | ||
Course Director: Prof. David T. Yue, [email protected] |
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| Course Webpage: | ||
| Course Mechanics: | ||
Course notes will be posted on course web page, along with links to reading materials. For undergrads, grading is determined from homework (60%) and a final exam (40%). For graduate students, grading is determined from homework (40%), class presentations (20%) and final exam (40%). Homework, when assigned, will be posted on Thursdays and is due in Traylor 726 on the Friday of the following week, before noon. Homework will not be accepted after 5p on the Fridays they are due. The final exam will be 2 hours in duration, starting at the usual lecture time. |
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